A rise in non-communicable disease is predominantly due to unhealthy urban lifestyles such as work stress, sedentary lifestyle and unhealthy eating habits. That is why there are many people struggling with depression, osteoarthritis and liver disease. SAM-e is a natural molecule that presents in the cells of the body. It can also be synthesized. It regulates over 100 different key functions in the body and is involved in the formation, activation or breakdown of other chemicals in the body, including hormones, proteins and certain drugs.
In the US and Malaysia, SAM-e is classified as a supplement but in some parts of the European countries, SAM-e is classified as a prescription drug. In general, SAM-e is beneficial in depression, osteoarthritis and liver disease. Its involvement in methylation assists in cellular growth, repair and maintains the action of several hormones and neurotransmitters that affect mood. The highest concentration of SAM-e is found in the brain and liver. SAM-e takes at least a month to experience its full benefits.
SAM-e ‘s most significant benefits are found in the liver. The liver contains one of the highest amounts of SAM-e in the body. SAM-e is necessary for liver function and it is the basic nutrient for this organ. One of the liver’s most important functions is in the detoxification process. The liver is constantly under attack by toxins. The human body can work wonders by developing a detoxification system that is able to cope with the toxic load in the body. This little miracle nutrient is known as glutathione, the bodies’ number one defense against toxicity. Glutathione needs SAM-e to produce it. It is known as ‘the master antioxidant’. The toxin is attached to glutathione to be converted to water-soluble substance so it can be removed from the body. Natural production of glutathione declines with age especially if a person has poor sleeping habits, bad dietary habits, under constant stress and alcohol consumption. These bad lifestyle habits not only deplete the glutathione levels but also restrict the natural replenishment of glutathione. Thus, SAM-e helps to reboot the liver detoxification process by producing glutathione to make the liver efficient again. However, it may take from 6 months to a year to feel any improvement from glutathione.
One liver tonic commonly used is called milk thistle. Milk thistle provides immediate protection on the liver through formation of a protective layer or shield to prevent the reactive oxygen species (ROS) from attacking the liver cells. It also acts as an antioxidant to reduce the ROS. The combination of SAM-e and milk thistle is perfect to help to reboot and restore the liver function.
Studies have demonstrated that osteoarthritis is related to oxidative stress and ROS. Oxidative stress is due to a disturbance of the pro-oxidant and antioxidant balance. The pro-oxidant process is favoured in osteoarthritis, thus, leading to a ruptured joint balance that leads to the breakdown processes. These processes are activated by pro-inflammatory mediators such as cytokines and reactive oxygen species (ROS). When there are injuries to the joints, the pro-inflammatory enzymes COX and LOX will kick in. They are the most important enzymes that act like an alarm system to give warning to the bodies when there are injuries occurring. SAM-e works at the cellular level to slow down the damage at the joints. It tackles the root cause of the problem by reducing the production of ROS and increasing the antioxidants in the body. This will prevent the wear and tear of the joints, which subsequently leads to cartilage damage and osteoarthritis. SAM-e also has an analgesic effect that is similar to painkillers such as ibuprofen and Celebrex. The analgesic effects of SAM-e are not fully understood. SAM-e takes longer to provide pain relief as compared to common drugs. Having said that, it is a safer and equally effective alternative for joint pain problems.
A herbal analgesic and anti-inflammatory, Boswellia is popular for its rapid pain relief, as fast as five days. The marriage between SAM-e and Boswellia is an ideal union. SAM-e regenerates the joints by restoring the internal antioxidant system while providing long-term protection on the joints, while boswellia, on the other hand, stops the inflammation and reduces the pain fast.
Our brain controls our thoughts, feelings and behaviours. Preserving our mind and mood is a health skill that is important for everyone. Our mood affects every aspect of our life from how we feel about ourselves to the relationship with those around us. Constant life changes and hectic lifestyles put a lot of stress on our brain. Stress may be good to some people because it gives them the motivation to excel. However, excessive and constant stress induces ROS to accumulate in the brain and causes brain fog or slow reactions. SAM-e acts as an antioxidant that increases glutathione levels. Glutathione functions to reduce brain and nerve aging. It keeps the brain young and healthy. The antioxidant effect of glutathione is essential for detoxification of ROS in the brain cells. Oxidative stress is caused by imbalances between pro-oxidation, where a lot of ROS is produced, and anti-oxidation of the ROS through detoxification of ROS in the brain cells. The compromised balance between generation and detoxification of ROS has been connected to brain aging and neurodegenerative diseases. SAM-e also activates all the neurotransmitters to uplift the mood and improves social interactions. The human brain has many folds for learning, memory, judgement, our five senses and language.
Mind is how the brain interprets what we see, what we hear, what we learn and what we remember. Bacopa enhances the memory, cognition and learning power. It helps the brain to fight free radicals and increases neurotransmitters fast. Bacopa has been proven to boost intelligence, better memory and to think faster. Combining Bacopa with SAMe will help you feel good, think bright and live happy.
It may take longer to work its magic. But it manages the root cause of the problem. Combination with natural herbs such as milk thistle, boswellia and bacopa provides synergistic effects and provides an instant relief and long term solution to problems such as liver, joints and brain.